Replication of H2N2 influenza viruses in respiratory organs and brain of mice.

<p>Groups of 6 female CBA mice were infected i.n. with the corresponding viruses at a dose of 100 MID₅₀ in a volume of 50 µl. Three days after inoculation, mice were euthanized and lungs and nasal turbinateswere harvested. Virus titers in the organs were determined by end-point titration in eggs and expressed as log₁₀EID₅₀/ml. Significant lower titers with respect to the donor viruses are indicated by * (p<0,05) or ** (p<0,005). Bars indicate the average titer.