Competition studies of pathway mutants.

<p>(A) <i>In vitro</i> competition studies of the various mutants and their complemented strains in different growth media (n equals the number of independent <i>in vitro</i> competition experiments performed with each carbon source). (B) <i>In vivo</i> lung competition of the various mutants and their complemented strains after 24 h, where n equals the number of mice in each group that were inoculated with a total of 6×10⁶ CFU/mouse. The solid red line indicates the geometric mean of the competitive indices (CI) in each competition group. CI<1 indicates the mutant was less competitive than its complemented strain in various growth media (A) or within the lungs (B). Numbers above the red line represent the average total recovered CFU/mouse for each competition group.