Competitiveness of various Island mutants in the pneumonia/sepsis model.

<p>Data are combined from duplicate experiments. Mice were inoculated with approximately 3×10⁷ CFU/mouse of a combination of WCH206 and either WCH206 ΔROK, ΔPTS, ΔSulfatase or ΔIsland, at average input ratios of 1.75, 0.5, 1.65 and 1.45, respectively. The CIs were calculated on days 1, 2 and 3 for the nasopharynx (nasopharyngeal tissue and wash combined), lungs, blood and ears, and the mean log₁₀ CIs are indicated by black, horizontal bars. The neutral value is 0 (indicated by a broken, horizontal line). One sample <i>t</i>-tests were used to analyze the data (hypothetical value = 0): *, <i>P</i><0.05, **, <i>P</i><0.01, ***, <i>P</i><0.001.