<p>(A). p<i>53</i>: p<i>53</i> expression was highest (<i>p</i><0.05) during 7 hpf, Beyond 24 h, p53 did not show any expression. p53 expression was not detected in normoxic embryos,. (B). Caspase 3: Caspase-3 showed significantly higher (p<0.05) expression in early stages during 2 hpf (cleavage stage) in hypoxia exposed embryos compared to control (normoxia). Different superscripts indicate significant differences (<i>p</i><0.05) amongst hypoxic and normoxic groups at different times. Values are expressed as mean ± SEM (n = 10).</p
Unexplained intrauterine growth restriction (IUGR) may be a consequence of placental insufficiency; ...
AbstractMammalian embryos develop in a low oxygen environment. The transcription factor hypoxia indu...
<p>To verify the effects of hypoxia, nutlin-3, and pifithrin-α on changes in p53 level or activity, ...
<p>(A). Bcl-2 assay: Bcl-2 reached its highest (p<0.05) level in cell lysates during 24 hpf. Bcl-2 e...
Background: To evaluate the influence of hypoxia and molecular events in endothelial and embryonic s...
Hypoxia is a global phenomenon affecting recruitment as well as the embryonic development of aquatic...
<p>At H72 (3d), less than 5 cells per HPF expressed the caspase-3. Other types of cells (islets, duc...
<p>Each genetic alteration would lead to specific changes in gene expression but changes mediated by...
Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not essent...
<p>A, 24 hours after exposure to 1 µM etoposide, 6 µM cisplatin or 0.14 µM doxorubicin for 1 hour in...
<p><b>A:</b> For BDNF, the relative mRNA expression for each group was: 21% (n = 10) 914.6 (909), 40...
<p>A: Western blot analysis of HIF-1α in A549 cells under different levels of hypoxia (n = 3). B: We...
Cytotrophoblast (CT) cells isolated and purified from term placenta are able to differentiate into s...
The essentially infinite expansion potential and pluripotency of human embryonic stem cells (hESCs) ...
<p>HepG2, A549, U2OS, MDA-MB231, HT-29, Hep3B and PC-3 cells were incubated under normoxia (N, 21% O...
Unexplained intrauterine growth restriction (IUGR) may be a consequence of placental insufficiency; ...
AbstractMammalian embryos develop in a low oxygen environment. The transcription factor hypoxia indu...
<p>To verify the effects of hypoxia, nutlin-3, and pifithrin-α on changes in p53 level or activity, ...
<p>(A). Bcl-2 assay: Bcl-2 reached its highest (p<0.05) level in cell lysates during 24 hpf. Bcl-2 e...
Background: To evaluate the influence of hypoxia and molecular events in endothelial and embryonic s...
Hypoxia is a global phenomenon affecting recruitment as well as the embryonic development of aquatic...
<p>At H72 (3d), less than 5 cells per HPF expressed the caspase-3. Other types of cells (islets, duc...
<p>Each genetic alteration would lead to specific changes in gene expression but changes mediated by...
Remarkably, the p53 transcription factor, referred to as “the guardian of the genome”, is not essent...
<p>A, 24 hours after exposure to 1 µM etoposide, 6 µM cisplatin or 0.14 µM doxorubicin for 1 hour in...
<p><b>A:</b> For BDNF, the relative mRNA expression for each group was: 21% (n = 10) 914.6 (909), 40...
<p>A: Western blot analysis of HIF-1α in A549 cells under different levels of hypoxia (n = 3). B: We...
Cytotrophoblast (CT) cells isolated and purified from term placenta are able to differentiate into s...
The essentially infinite expansion potential and pluripotency of human embryonic stem cells (hESCs) ...
<p>HepG2, A549, U2OS, MDA-MB231, HT-29, Hep3B and PC-3 cells were incubated under normoxia (N, 21% O...
Unexplained intrauterine growth restriction (IUGR) may be a consequence of placental insufficiency; ...
AbstractMammalian embryos develop in a low oxygen environment. The transcription factor hypoxia indu...
<p>To verify the effects of hypoxia, nutlin-3, and pifithrin-α on changes in p53 level or activity, ...