Distribution of rankings of worm models of neurodegenerative diseases.

<p>The x-axis represents the log of the gene ranking bin boundaries, arranged in decreasing gene-product connectedness from left to right. The y-axis represents the log of the fraction of genes in each bin (where 100% is 135, 23, 22 & 52 genes for panels A, B, C & D respectively). The dashed line shows the linear regression for the worm screen results. The results of the screens are shown as black diamonds and results of random simulations are shown as empty triangles. (A) polyglutamine screen; (B) α-synuclein screen; (C) tau screen; (D) GWAS candidate white+grey zone genes for AD.