Impaired proliferation of β-cells in <i>MafA</i> KO mice.

<p>(A, B) Representative islets of <i>MafA</i> KO mice and their wild-type littermates 24 hours after the injection of BrdU (100 mg BrdU/kg body weight). BrdU (green), insulin (red) and DAPI (blue). (C) Quantification of the BrdU⁺ cells among the insulin⁺ cells. In total, 1706 insulin⁺ cells were counted in the <i>MafA</i> KO pancreas, and 1262 insulin⁺ cells were counted in the wild-type pancreas. The proliferation of β-cells in <i>MafA</i> KO mice was impaired. n = 3. The data represent the mean ± S.E.M. Bar, 20 µm.