TRPV2 is expressed in the peri-infarct zone of invading macrophages.

<p>For IHC analysis (panel A), sections derived from the infarcted zone were stained with either TRPV2 (panels i-iv) or with the monocyte/macrophage marker rat CD68 (panels v-viii). The sections were derived from one of the following time points post LAD occlusion: 1 day (i & v), 3 days (ii & vi), 10 days (iii & vii) and 30 days post procedure (iv & viii). Solid arrows represent positive staining. For IFC analysis (panel B), typical fluorescent images of CD68 AF 488- (green; i & v), TRPV2 AF 594 (red; ii & vi), and merges of the two markers as well as DAPI (iv & viii) are given for LV sections from three days post MI. Panels B i-iv represent the peri-infarct area, while panels v-viii- represent areas remote to the infarct zone, in the same slides. Arrowhead represents several cells stained with both CD68 and TRPV2. The dashed arrows show the infarct zone. The square in panel B iii and vii represent areas that were digitally zoomed in and are given in panels B iv and viii, respectively.