Human-mouse ChIP-seq factor-bound region overlap.

a<p>The first row in each section gives the total number of ChIP-seq peaks with binding sites in humans within the (−100,+100) window separated into categories. The second row shows the number of these peaks also containing a TFBS in the orthologous regions in mouse, while the third row gives the number of aligned binding sites across the two species. Percentages are given with respect to the total number of shared and lineage-specific ChIP-seq peaks for each factor.</p>b<p>Shared peaks are human ChIP-seq peaks within 200 bp of a ChIP-seq peak summit in the orthologous region in mouse. Analogous cell types were used across species (GATA1: Erythroblasts, SOX2: Embryonic stem cells, MYC, MAX, ETS1, CTCF: B-lymphocytes).</p>c<p>Lineage-specific peaks in human are not within 200 bp of a mouse ChIP-seq peak in the analogous cell type. Only human peaks with identifiable orthologous regions in mouse were included.</p>d<p>The numbers (and fractions) of human ChIP-seq peaks in each category containing binding motif occurrences estimated to be present in the human-mouse ancestor (‘Ancestral sites’).</p>e<p>The numbers (and fractions) of human ChIP-seq peaks in each category containing only binding motif occurrences originating after human-mouse divergence (‘Lineage-specific sites’).