ChIP-seq data show co-localization of TCF21, AHR and ARNT binding in loci containing genes related to inflammation and programmed cell death.

<p>(a) Venn diagram showing intersection of the TCF21, AHR and ARNT ChIP-seq peaks. Note that the shown number of overlapping AHR-ARNT-TCF21 sites is colored in light gray to indicate that it is a subgroup of the shown intersections of individual pairs. (b) GO terms related to the overlap of TCF21, AHR and ARNT ChIP-seq sites. GO terms were defined using 119 overlapping sites from a, and by identification of related genes with GREAT. Calcium signaling GO terms are noted to represent a broad array of cytokines and chemokines in addition to other types of molecules. (c) Overlap of AHR ChIP-seq binding sites and GWAS SNPs in a window of +/-2000bp. GWAS SNPs were obtained from the GWAS Catalog, parsed into categories and the binomial enrichment of overlap with the AHR ChIP-seq sites was calculated for each parsed category. Plotted are binomial fold change vs.–log binomial p-value and terms were colored according to the four major categories: brain, cancer, cardiovascular, chronic inflammatory. (d) Overlap of ARNT ChIP-seq binding sites and GWAS SNPs in a window of +/-2000bp. (e) Overlap of TCF21 ChIP-seq binding sites and GWAS SNPs in a window of +/-2000bp. (f) Overlap of AHR-ARNT-TCF21 ChIP-seq binding sites and GWAS. SNPs in a window of +/-2000bp.