Comparison of body weight, survival and viral load between knock-out and wild type mice after infection with influenza A H1N1 virus.

<p>Female mice were infected with 2×10⁵ FFU PR8 (H1N1) virus and body weight loss (A) and survival (B) were monitored until day 14 p.i. Mice with a weight loss of more than 30% of the starting body weight were euthanized and recorded as dead. Viral load was determined in infected lungs at days 2 and 5 p.i. (C). Weight loss data represent mean values +/− SEM. Note that for the later time points, only data of surviving mice are presented. Body weight loss was not significantly different between wild type (C57BL/6N- <i>Ifi27l2a^+/+</i>) and homozygous <i>Ifi27l2a^-/-</i> mutant mice (using the Mann Whitney U test). Survival (using the log-rank test) and viral load in infected mice at days 2 and 5 after infection (using the Mann Whitney U test) were not significantly different between wild type and knock-out mice.