Change in body weight and survival in infected mice.

<p>(<i>A)</i> Weight loss was similar in surviving influenza A-infected <i>Ctsl</i>^-/- and <i>Ctsl</i>^+/+ mice. Data shown are means ± SEM, with no significant difference between genotypes (<i>t</i>-test). (<i>B)</i> Survival in infected <i>Ctsl</i>^+/+ mice over the same 14-day interval was better than in infected <i>Ctsl</i>^-/- mice (<i>P</i> = 0.0037 by log-rank test). No deaths occurred in sham-infected mice of either genotype. <i>N</i> = 5, 5, 23 and 32 in sham-infected <i>Ctsl</i>^-/-, sham-infected <i>Ctsl</i>^+/+, infected <i>Ctsl</i>^-/-, and infected <i>Ctsl</i>^+/+ mice, respectively.