NKG2A^−/− mice demonstrate greater lung damage from enhanced inflammation during acute influenza infection.

<p>Mice were intranasally infected with a sub-lethal dose of influenza A/PR8/34. On day 10 post-infection, mice were euthanized by anesthesia overdose and exsanguination. Lungs were process as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108385#s2" target="_blank">materials and methods</a> for histological sections, slides were H & E stained and evaluated for histopathological damage. Percent of total area of damaged lung per 4× field was calculated for each lung slice. Data is presented as % inflamed lung. Data is representative of two distinct experiments of 2–4 mice per group. **** p<0.0001.