(A–C) Histological analysis of lung sections taken from Cd59a, WT and age-matched WT controls

Lung histology (H&E stain) demonstrating pulmonary injury 8days after infection with influenza virus (=9/group). Representative views of mouse lungs (×20original magnification) from WT(A) or Cd59a (B) mice infected with influenza are shown. A representative section from an uninfected WT control (C) is also included. In Cd59a mice there is mild hyperplasia of alveolar type-II cells and an extensive infiltrate of mononuclear cells into the interstitium (arrows). The alveolar walls contained dilated capillaries filled with RBC, with mild fibrotic changes (f) and perivascular lymphocytic infiltrates (g). In the healthy lung (C), the alveoli (a), alveolar septa (s) and alveolar duct (d) are marked for comparison. (D) Mice on the Balb/c background were infected with influenza virus and weight was monitored daily. Results represent mean values ± SEM of five mice per group. Statistical significance was evaluated using the Student's -test. value was <p><b>Copyright information:</b></p><p>Taken from "CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and-independent mechanisms"</p><p></p><p>European Journal of Immunology 2007;37(5):1266-1274.</p><p>Published online Jan 2007</p><p>PMCID:PMC2435422.</p><p>Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim