Effect of individual mast cell releasate components on macrophage LOX-1 expression.

<p>Monocyte-derived macrophages were incubated with A) histamine, B) TNF-α, and C) TGF-β1 for 4 h and 24 h, and analyzed for LOX-1 mRNA expression (n = 6 donors). D) The combined effect of the components was studied by incubating macrophages with histamine (10 µM) and/or TNF-α (1 ng/ml) and/or TGF-β1 (0.1 ng/ml) for 4 h and 24 h (n = 4 donors). The results are presented as means ± SEM. *p<0.05, **p<0.01 vs. non-treated cells.