Time-dependent dependent mast cell releasate-induced changes in macrophage scavenger receptor mRNA expression.

<p>A) Monocyte-derived macrophages (MDM) from 3 donors were cultured in human primary mast cell releasate for 72 h, and LOX-1 mRNA expression was analyzed and compared to non-treated cells at the beginning of the incubation. B) MDMs from 6 donors were cultured in LAD2 mast cell releasate for 4 h and 24 h, and LOX-1, CD36 and MSR1 mRNA expression was measured and compared to non-treated cells at each time point. C) MDMs from 3 different donors were incubated in complete releasate, soluble releasate, or granules derived from LAD2 mast cells for 4 h and 24 h. The results are presented as means ± SEM. *p<0.05, **p<0.01 vs. non-treated cells.