<p>List of residues (as identified from the crystallographic structure of GluCl<sub>Cryst</sub> and predicted by the GluCl<i>Ac</i>2 homology model) accompanied by their position number in the alignment of Fig. 2 and a description of the type of interactions in which they are involved. Residue numbers are given for the crystalized receptor (GluCl<sub>Cryst</sub>), the receptor used in the electrophysiological experiments (GluClα2b), and the receptor that figures in the homology model (GluCl<i>Ac</i>2) from left to right, respectively. Rows in green, yellow and red indicate identical, similar and different aligned residues, respectively.</p
<p>The GluCl sequence was used as template for homology modeling throughout the GABA<sub>A</sub>R su...
Glutamate is the main excitatory neurotransmitter in the brain and is essential in most physiologic...
ABSTRACT: Ionotropic glutamate receptors (GluRs) are ligand-gated membrane channel proteins found in...
<p>A. 3D representation of the binding pocket of glutamate at the interface between the two subunits...
<p>Sequence alignment of residues of the two GluCl receptors: the first, a receptor from <i>C. elega...
<p>2D diagram representing the interactions between the binding pocket residues of the homology mode...
<p>The alignment contains the sequences from four invertebrate glutamate-gated chloride channels (Gl...
The publication of the first high-resolution crystal structure of a eukaryotic Cys-loop receptor, Gl...
<p>Individual alignments for the receptors and the G-proteins are shown. A colored background indica...
<p>Only two adjacent subunits are explicitly displayed, the three others are represented by the tran...
<p>Residues in the receptor-G-protein interfaces of the simulation systems are shown as sticks. The ...
<p>Top: uncorrected P distance based NeighborNet of residues forming the ligand binding sites in GPC...
A three-dimensional model of the amino terminal domain (ATD) of the mGluR1 receptor subtype was cons...
<p>A. Mutations in four binding residues of GluCl<i>Ac</i>2: Y96, R98, R135 and Y161 (positions 54, ...
A model is presented for the interaction between G proteins and G protein-coupled receptors, the mod...
<p>The GluCl sequence was used as template for homology modeling throughout the GABA<sub>A</sub>R su...
Glutamate is the main excitatory neurotransmitter in the brain and is essential in most physiologic...
ABSTRACT: Ionotropic glutamate receptors (GluRs) are ligand-gated membrane channel proteins found in...
<p>A. 3D representation of the binding pocket of glutamate at the interface between the two subunits...
<p>Sequence alignment of residues of the two GluCl receptors: the first, a receptor from <i>C. elega...
<p>2D diagram representing the interactions between the binding pocket residues of the homology mode...
<p>The alignment contains the sequences from four invertebrate glutamate-gated chloride channels (Gl...
The publication of the first high-resolution crystal structure of a eukaryotic Cys-loop receptor, Gl...
<p>Individual alignments for the receptors and the G-proteins are shown. A colored background indica...
<p>Only two adjacent subunits are explicitly displayed, the three others are represented by the tran...
<p>Residues in the receptor-G-protein interfaces of the simulation systems are shown as sticks. The ...
<p>Top: uncorrected P distance based NeighborNet of residues forming the ligand binding sites in GPC...
A three-dimensional model of the amino terminal domain (ATD) of the mGluR1 receptor subtype was cons...
<p>A. Mutations in four binding residues of GluCl<i>Ac</i>2: Y96, R98, R135 and Y161 (positions 54, ...
A model is presented for the interaction between G proteins and G protein-coupled receptors, the mod...
<p>The GluCl sequence was used as template for homology modeling throughout the GABA<sub>A</sub>R su...
Glutamate is the main excitatory neurotransmitter in the brain and is essential in most physiologic...
ABSTRACT: Ionotropic glutamate receptors (GluRs) are ligand-gated membrane channel proteins found in...