Alignment used for homology model building.

<p>Sequence alignment of residues of the two GluCl receptors: the first, a receptor from <i>C. elegans</i>, GluCl_Cryst, which has been crystalized and which will serve as the template for the homology model of the second, GluCl<i>Ac</i>2, from the <i>Aplysia californica</i>. The numbers above the sequence represent the positions in the alignment based on the truncated receptor from GluCl_Cryst. The last line describes the secondary structure of GluCl_Cryst with the blue arrows representing β-sheets and the orange tubes, the α-helices. Throughout the length of the sequences, a light blue highlighting indicates identical or similar residues. Residues binding glutamate in GluCl_Cryst are surrounded by a black rectangle. These positions are highlighted in green, yellow and red when the aligned residue in GluCl<i>Ac</i>2 is respectively identical, similar or different. Three additional positions are surrounded by a red rectangle and correspond to positions of residues binding glutamate only in the homology model of GluCl<i>Ac</i>2.