Iguratimod decreased production of BAFF, IL-6, IL-17A and IL-21.

<p>(A) Serum BAFF concentrations of the same mice above. Each dot represents an individual mouse. The horizontal bars represent mean. (B) Relative mRNA expression levels of BAFF, IL-6, IL-21 and IL-17A in splenic cells. The mice received 8-week treatment of iguratimod, cyclophosphamide or vehicle solution. Data are represented as mean ±SEM. Statistics are calculated by non-paired student's t test (A) or two-tailed Mann-Whitney U test (B). * <i>p</i><0.05, **<i>p</i><0.01, *** <i>p</i><0.001.