Example of polymer conformations of the adapted DL model at different looping regimes.

<p>(<b>A</b>) Conformation of the adapted-DL polymer with high short-range (p_short = 0.12) and low long-range (p_long = 0.04) looping probabilities and (<b>B</b>) the same polymer with low short-range (p_short = 0.04) and high long-range (p_long = 0.12) looping probabilities. The colour code labels the monomers of the polymer according to the visible spectrum along the length of the polymer. The inset in panel A displays the same situation as in (A) after abolishing all long-range looping (p_long = 0), showing that a uniform thick fibre is formed. More adapted DL polymer conformations with the same looping probabilities as shown in (A) and (B) are shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003877#pcbi.1003877.s005" target="_blank">Figure S5</a>. (<b>C</b>) Conformation of the domain-adapted DL polymer with high short-range (p_short = 0.16) and low long-range (p_long = 0.02) looping probabilities and (<b>D</b>) the same polymer with low short-range (p_short = 0.02) and high long-range (p_long = 0.16) looping probabilities. Here, topological domains are labelled red and non-looping linker regions blue.