<p>(A) Targeted inhibitors from the CCLE database. (B) Targeted inhibitors from the Sanger COSMIC database. (C) Selected targeted inhibitors in our lab showing significant differences in sensitivity (except XAV939) towards the two clusters of cell lines. Y-axis is the IC<sub>50</sub> values in log10 scale. P-value is computed by Mann Whitney U-test. Horizontal bars are medians for sample distributions.</p
<p>Four curves represent the dose-response curve of HCPT, EM-d-Rha, Cisplatin, and Emodin against He...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...
<p>Each circle represents a marketed kinase inhibitor and its targeted cell growth inhibition. A: Ce...
a<p>The median log<sub>10</sub>IC<sub>50</sub> value (M) for each drug was used as a cut-off to sepa...
<p>There are 31 cell lines for small cell lung cancer. The boxplots show drugs listed on the x-axis ...
(a) Compounds with selective activity on cell lines with high or low CA20 score. The volcano plot sh...
<p>Using a single dose of 10 μM of the test compound against the NCI 60 cell lines. Zero on the X-ax...
<p>The diverse sensitivity of each Aurora kinase inhibitor in this panel against B-ALL (C1, SEM, B1,...
<p>Each row represents a separate cell line, and each column represents a separate compound tested. ...
<p>X axis represents the 4 treatment concentrations of endoxifen (3, 5, 7 and 10 μM) and Y axis repr...
a<p>The median inhibitory concentrations (IC<sub>50</sub>) were determined by nonlinear regression a...
<p>The summary pooled estimate (odds/hazard ratio) is indicated by rectangles, with the lines repres...
<p>Boxplots indicate the distribution of drug sensitivity values (based on IC50) in each cancer line...
<p>For each drug, and each cell line, the GI50 is shown as a bar on a logarithmic scale relative to ...
<p>Four curves represent the dose-response curve of HCPT, EM-d-Rha, Cisplatin, and Emodin against He...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...
<p>Each circle represents a marketed kinase inhibitor and its targeted cell growth inhibition. A: Ce...
a<p>The median log<sub>10</sub>IC<sub>50</sub> value (M) for each drug was used as a cut-off to sepa...
<p>There are 31 cell lines for small cell lung cancer. The boxplots show drugs listed on the x-axis ...
(a) Compounds with selective activity on cell lines with high or low CA20 score. The volcano plot sh...
<p>Using a single dose of 10 μM of the test compound against the NCI 60 cell lines. Zero on the X-ax...
<p>The diverse sensitivity of each Aurora kinase inhibitor in this panel against B-ALL (C1, SEM, B1,...
<p>Each row represents a separate cell line, and each column represents a separate compound tested. ...
<p>X axis represents the 4 treatment concentrations of endoxifen (3, 5, 7 and 10 μM) and Y axis repr...
a<p>The median inhibitory concentrations (IC<sub>50</sub>) were determined by nonlinear regression a...
<p>The summary pooled estimate (odds/hazard ratio) is indicated by rectangles, with the lines repres...
<p>Boxplots indicate the distribution of drug sensitivity values (based on IC50) in each cancer line...
<p>For each drug, and each cell line, the GI50 is shown as a bar on a logarithmic scale relative to ...
<p>Four curves represent the dose-response curve of HCPT, EM-d-Rha, Cisplatin, and Emodin against He...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...
Traditional means for scoring the effects of anti-cancer drugs on the growth and survival of cell li...