Fluorofenidone inhibits AKT activation in the diabetic kidneys of <i>db/db</i> mice.

<p>AKT activation (phosphorylation of AKT at serine 473, p-AKT), total AKT, and GAPDH in individual groups were determined by western blot; typical results from the 5-week old animals are shown (A). Quantification of western blot results is expressed as fold change compared to that in <i>db/m</i> mice. The symbols * and # represent <i>p</i><0.05 in comparison to <i>db/m</i> and the individual Ctrl mice, respectively (B). Three mice were used in individual groups.