Interaction of SNP-scores and protein intake.

<p>Average, yearly waist change (mm/y/5 E% protein/risk allele). A: protein replacing carbohydrate. B: protein replacing fat. SNP-score×protein interactions were calculated using linear regression and pooled estimates were calculated using random effect meta-analysis. The effect-estimates from the individual cohorts were weighted by the inverses of their variance (% weight). The results were adjusted for baseline waist circumference, height, sex, smoking status, physical activity, education, menopausal status for women and concurrent change in body weight. Abbreviations: BMI-score, sum of body mass index associated risk-alleles; WC-score, sum of waist circumference associated risk-alleles; WHR_BMI-score, sum of waist-hip ratio adjusted for BMI associated risk-alleles.