Interaction between genetic predisposition scores and 25-hydroxyvitamin D in relation to subsequent change in body weight.

<p>Abbreviations: BMI score, sum of body mass index associated risk-alleles; WC score, sum of waist circumference associated risk-alleles; WHR score, sum of waist-hip ratio adjusted for BMI associated risk-alleles; Composite score, sum of SNP associated to all three phenotypes. Results presented as annual weight change (g/y) effect-modification for each additional risk-allele per 10 nmol/L higher 25-hydroxyvitamin D. The study-specific SNP-score × 25-hydroxyvitamin D interactions were calculated using linear regression and corresponding meta-analysis results were derived using a random effects approach. The results were adjusted for baseline measure of body weight, height, gender, age, smoking status, alcohol consumption, physical activity, education, menopausal status for women and season of blood draw.