Hemodynamic and myocardial effects of EPO (open circles, n = 12) compared with vehicle control (closed circles, n = 12) in series <i>HS-65_BV</i>.

<p>Numbers in brackets indicate when the number of animals decreased from the preceding time point consequent to death of the animal. BL, baseline; BW, blood withdrawal; HS, hemorrhagic shock; NS, normal saline; BR, blood reinfusion; Ao, aortic pressure; SVRI, systemic vascular resistance index; LVSWI, left ventricular stroke work index; RVWI, right ventricular stroke work index. Values are shown as mean ± SEM. Differences between groups were analyzed by two-way repeated measures ANOVA. There were no overall significant treatment effects. However, there was an overall statistically significant interaction between treatment and time for Ao mean (<i>p</i> = 0.002). *<i>p</i>≤0.05, †<i>p</i>≤0.01, and ‡<i>p</i>≤0.001 denote statistically significant differences between groups at the specified time points. ^a<i>p</i>≤0.05, ^b<i>p</i>≤0.01, and ^c<i>p</i>≤0.001 denote significant differences <i>vs</i> baseline using the Holm-Sidak test for multiple comparisons showing the differences only when they occurred in one of the two groups.