Plk1 inhibition leads to senescence in multiple cell lines.

<p>A) Cells were treated for two weeks with MLN0905 (50 nM for HCT116, 30 nM for A549, 20 nM for SW480 and HT-29) and then stained for β-galactosidase activity. B) β-galactosidase staining was then quantified in senescent cells and represented as % area (shown is mean ±SD; *p = 0.0159, **0.0033 and ***0.032 by a two-tailed Mann-Whitney test).