UCEs are enriched for the TFBS.

<p>(<b>A</b>) Box plots represent results of one hundred sets (each set contains one thousand randomly chosen positions). The y-axis indicates actual ENCODE TFBS overlap per one thousand tested positions. Boxes show IQR, notches indicate 95% confidence intervals of the median, whiskers extend to 1.5 times the IQR and open circles show outliers. *** P<2.2×10⁻¹⁶, two- tailed Mann–Whitney test. (<b>B</b>) Prevalent SNV positions are depleted for TFBS. All rare and prevalent SNV positions from the three different populations were analyzed for the ENCODE TFBS overlap. Random UCE set represents randomly chosen UCE positions (G,C content matched) that had the same number of analyzed positions as the rare and prevalent SNVs. Prevalent and rare SNVs overlap with the TFBS overlap is shown as relative to random UCE positions. For the statistical analysis each set (Pearson's Chi-squared test) was individually tested. * P<0.01.