Prevalent and rare variants show distinctive conservation preference.

<p>(<b>A</b>) Distribution of A,T and G,C nucleotides in the UCEs and SNV positions. <b>(B–D</b>) Cumulative distribution plots of phyloP scores of SNVs with different MAFs. Data from three different data sources (<b>B</b>) SG-CHN, (<b>C</b>) ITA and (<b>D</b>) 1 KG are shown. Shaded grey area represents 95% confidence interval (obtained by bootstrapping) of random G/C content corrected UCE positions (blue line). Numbers in the parentheses indicate analyzed positions or SNVs.