Variation of the mean amount of food ingested by each group of mice along their lifespan.

<p>Data are calculated as food intake per mice and per day. Each data was obtained as mean±s.e, n = 5 (5 mice cages containing 10 mice each). The bar diagrams shows the mean±s.e. of all the measurements obtained for each group of mice (n = 197 measurements for whole period, n = 112 for the first 12 months, n = 85 for 13–21 months) and the significance (*, p<0.05; **, p<0.005; ***, p<0.001) of the differences (HC group, compared with the control; Hk, HK and HR groups, compared with the HC group).