<p>(A, B) Naïve CD8<sup>+</sup> T cells from STZ-diabetic (red line), STZ-non-diabetic (blue line) and control (gray-filled) C57BL/6 mice were stimulated by anti-CD3/CD28 antibodies <i>in vitro</i>. At 24 and 72 hours after stimulation, the production of perforin and TNFα was checked by intracellular staining and analyzed by flow cytometry. (C) At 120 hours of antigenic stimulation, 2C CD8<sup>+</sup> T cells from STZ-diabetic (red line) and STZ-non-diabetic (gray-filled) mice were harvested and surface CD103 expression was checked and analyzed by flow cytometry. Staining of isotype control for the three experimental groups was shown: STZ-non-diabetic (blue dot), STZ-diabetic (red dash) and control (black line) mice. (D) CD103-positive popu...
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent ...
<p>(A) Frequency of CD4+ T cells (left panel) and CD8+ T cells (middle panel) as well as CD4-to-CD8 ...
RIP-B7.1 mice expressing the co-stimulator molecule B7.1 (CD80) on pancreatic beta cells are a well-...
<p>(A) CFSE-labeled STZ-diabetic, STZ-non-diabetic and control naïve CD8<sup>+</sup> T cells from C5...
<div><p>Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens...
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortali...
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortali...
<p>NOD mice received IDO-expressing fibroblasts upon initiation of spontaneous diabetes. At the endp...
<p>(<b>A</b>) PD-L1<sup>−/−</sup> mice were immunized with pCI (group 1, n = 3), pCI/ppins (group 2,...
Type 1 diabetes is an autoimmune disease resulting in the loss of insulin production and, consequent...
<p>Mice (3/group) which had been transplanted i.p. with 3 × 10<sup>6</sup> ID8 cells 10 days earlier...
<p>Diabetes mellitus has been known not only to associate with an increased risk of cancers but also...
<p>A. On day 45 after the second immunization, splenocytes were stained anti-CD4-FITC, anti-CD62L-PE...
<p><b>A)</b> Total numbers of 2° M Thy1.1 P14 CD8 T cells in mL of PBL, and in the spleen, lung, and...
<p>(<b>A</b>) TAP-deficient RMA-S cells were either not pulsed (−/−) or pulsed for 6 h with high dos...
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent ...
<p>(A) Frequency of CD4+ T cells (left panel) and CD8+ T cells (middle panel) as well as CD4-to-CD8 ...
RIP-B7.1 mice expressing the co-stimulator molecule B7.1 (CD80) on pancreatic beta cells are a well-...
<p>(A) CFSE-labeled STZ-diabetic, STZ-non-diabetic and control naïve CD8<sup>+</sup> T cells from C5...
<div><p>Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens...
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortali...
Emerging evidences have shown that diabetes mellitus not only raises risk but also heightens mortali...
<p>NOD mice received IDO-expressing fibroblasts upon initiation of spontaneous diabetes. At the endp...
<p>(<b>A</b>) PD-L1<sup>−/−</sup> mice were immunized with pCI (group 1, n = 3), pCI/ppins (group 2,...
Type 1 diabetes is an autoimmune disease resulting in the loss of insulin production and, consequent...
<p>Mice (3/group) which had been transplanted i.p. with 3 × 10<sup>6</sup> ID8 cells 10 days earlier...
<p>Diabetes mellitus has been known not only to associate with an increased risk of cancers but also...
<p>A. On day 45 after the second immunization, splenocytes were stained anti-CD4-FITC, anti-CD62L-PE...
<p><b>A)</b> Total numbers of 2° M Thy1.1 P14 CD8 T cells in mL of PBL, and in the spleen, lung, and...
<p>(<b>A</b>) TAP-deficient RMA-S cells were either not pulsed (−/−) or pulsed for 6 h with high dos...
The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent ...
<p>(A) Frequency of CD4+ T cells (left panel) and CD8+ T cells (middle panel) as well as CD4-to-CD8 ...
RIP-B7.1 mice expressing the co-stimulator molecule B7.1 (CD80) on pancreatic beta cells are a well-...