L27/01_F increases recruitment of host cells to the lungs, but decreases cytokine production.

<p>L27/01 and L27/01<b>_F</b> strains elicit different inflammatory response in C57/BL6 mice. Mice (n = 8) were inoculated i.t. with 10⁶ yeast cells of L27/01 or L27/01<b>_F</b> strains. After 1, 7, 15 or 30 days post infection, the mice were euthanized and mononuclear leukocytes (<b>A</b>) and neutrophils (<b>B</b>) in bronchoalveolar lavage fluid (BALF) were quantified. Neutrophilic infiltrate in the lungs was also determined as MPO activity and expressed as relative number of neutrophils (<b>C</b>). Levels of CXCL1/KC (<b>D</b>), IFN-γ (<b>E</b>), TNF-α (<b>F</b>) and IL-10 (<b>G</b>) are expressed in pg per 100 mg of lung. White bars refer to not infected (NI) animals, black bars to animals infected with the L27/01 strain, and grey bars to animals infected with the L27/01<b>_F</b> strain. The results are presented as the mean ± SEM. Each experiment was performed in triplicate. *P<0.05 was considered to be significant.