Amelioration of systemic inflammation and NGF up-regulation in cholestatic liver-bearing mice by methylprednisolone (MP).

<p>The mice receiving bile duct ligation surgery immediately underwent intraperitoneal administration with either normal saline (NS, n = 5) or MP (n = 3) at 1 mg/kg/day for 14 consecutive days. Mice plasma and liver extracts were collected and subjected to ELISA (A) and RT-qPCR analyses (B), respectively. Inflammatory cytokines measured included TNF-α, IL-6, NGF, and TGF-β1. Data are shown in mean±SEM. * indicates <i>P</i><0.05 compared to NS group.