Sequencing logos depicting the statistically significantly enriched motifs identified in the high-confidence p53 ChIP-seq peaks in HCT116, in IMR90 [16], and in a set of 168 p53 reference sites (p53 REF SET), see Materials and Methods.

<p>Analysis was done with the MEME suite <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113492#pone.0113492-Bailey1" target="_blank">[42]</a>, using the programs MEME-ChIP <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113492#pone.0113492-Machanick1" target="_blank">[48]</a> and DREME <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113492#pone.0113492-Bailey3" target="_blank">[46]</a>. Shown is the distribution of the identified motifs in 100 nt windows centered at the peak maxima, reported by CentriMo <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113492#pone.0113492-Bailey2" target="_blank">[43]</a>.