Correlation between tumor volume and area under the mutation peaks.

<p>The results of T790M (A, B, C) and L858R (D, E, F) are shown. Correlation with tumor volume of primary lesion (A, D), metastatic lesions (B, E), or total tumor lesions (C, F) and area under the mutation peaks were analyzed. After inoculation with H1975 into dorsal flanks, six mice were sacrificed monthly from one month to four months, and plasma samples were collected. T790M and L858R were determined using the MBP-QP method, and the areas under the peaks were measured using i-densy AreaAna. Tumor volumes of primary lesions and metastatic lesions were weighed after dissection. ρ: Spearman rank correlation coefficient; p: p value.