Changes of tumor volumes and weights in response to therapy.

<p>SNU-16 stomach tumor-bearing mice that were analyzed for imaging signals after the first and second round of treatment were maintained for the measurement of tumor size. (A) (B) Measurement of tumor volumes at 3 weeks after treatment. (C) (D) Measurement of weights of isolated tumor mass at 3 weeks after treatment. <i>* p</i><0.05, ** <i>p</i><0.01, and *** <i>p</i><0.001 by one-way ANOVA. Arrows represent the time points of treatment. Asterisks represent statistical significance compared to PBS. Asterisks on brackets represent significance in difference between the two groups. (E) TUNEL staining of tumor tissues. Green, apoptotic cells; Blue, nucleus. PBS, phosphate-buffered saline; CPT, cisplatin; CET, cetuximab; CPT+CET, cisplatin plus cetuximab. Scale bars represent 50 µm.