Working memory: performance in Y-maze.

<p>A. The baseline rate of spontaneous alternations in Y-maze was lower in the vehicle-treated Ts65Dn vs. 2N mice, reflecting an impairment of working memory. JZL184-treatment had no effect on the performance of both 2N and Ts65Dn mice suggesting no effect on working memory. B. The number of ‘arm entries’ during the Y-maze test was greater in vehicle-treated Ts65Dn vs. 2N mice reflecting increased locomotion of Ts65Dn mice. JZL184-treatment reduced this parameter to the levels seen in 2N animals.