Histopathology of the organs collected from the immunized group animals on 3^rd and 20^th day post infection with <i>Y. pestis</i> and the naive control animals that were neither immunized nor challenged with <i>Y. pestis</i>.

<p>Tissue sections were stained with hematoxylin and eosin for pathological examination. Tissue section collected from naive control and immunized animals on 3^rd day post infection <i>i.e.</i>, Naive control (A); PBS control (B); HSP70(II) (C); F1 (D); F1+HSP70(II) (E); LcrV (F); LcrV+HSP70(II) (G); F1+LcrV (H); F1+LcrV+HSP70(II) (I). Tissue sections were collected from the survived animal groups on 20^th day post infection <i>i.e.</i>, LcrV (J); LcrV+HSP70(II) (K); F1+LcrV (L); F1+LcrV+HSP70(II) (M). Photomicrograph represents the histopathology of Lung[<b>a</b>]: the arrows in the panel B indicate the infiltration of neutrophils. Photomicrograph of spleen [<b>b</b>]: in the panel B, reduced density of white pulp follicle and congestion in the red pulp, lymphoid follicle depletion shown by arrow and the presence of megakaryocytes shown by bold arrow. Photomicrograph of kidney [<b>c</b>]: the granular degeneration of parenchyma was observed in the panel B (bold arrows) and swelling in renal tubules (arrows). Photomicrograph of liver [<b>d</b>]: in the panel B, the hepatocytes degeneration was observed as indicated by arrow.