Heatmap of the fitting residuals for simulated data generated for different protein half-lives and for different strengths of global physiological effects.

<p><i>A:</i> For all different combinations of 33 half-lives of FlgM (horizontal axis) and FliA (vertical axis), the residual of the fit for a model ignoring protein kinetics is represented by the color code reported in the right bar. For clarity of presentation, the residual values <i>Q</i> have been normalized with respect to the maximum value of <i>Q</i> over all half-life combinations. The combination corresponding to the measured half-lives in LB medium is marked with a light blue square (18 min for FlgM, 30 min for FliA). <i>B:</i> For 26 different values of the strength parameter <i>α</i>, defined in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004028#pcbi.1004028.e004" target="_blank">Eq. 4</a>, the residual of the fit by a model ignoring global physiological effects is represented by the color code. The residual values <i>Q</i> have been normalized with respect to the maximum value of <i>Q</i> over the different strengths of physiological effects. The value corresponding to the real data is marked with a light blue rectangle (<i>α</i> = 1).