<p><b>a)</b> Agarose gel showing the effect of the tested compounds on NF-κB:DNA complex formation. Each lane indicates the number of the compound in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115819#pone.0115819.g002" target="_blank">Fig. 2</a>. B1 is the positive control <b>28</b>, while B2 is the negative control. <b>b)</b> Response for each compound (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115819#pone.0115819.g002" target="_blank">Fig. 2</a>) compared to the positive control <b>28</b>. The error bars indicate the standard deviation.</p
<p>A: BPI chromatogram in negative ESI mode. B: BPI chromatogram in positive ESI mode. C: The bioact...
<p>Samples were loaded on a 2% agarose gel in TAE (1x) buffer. Lanes containing Nupr1 + non-damaged-...
<p>To determine the effect of compounds on the blockage of Pol-β-activity, we assembled <i>in vitro<...
<p>Compounds tested as inhibitors of the NF-κB:DNA-recognition target complex formation.</p
The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodi-meric co...
<div><p>The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodim...
<p><b>a)</b> Agarose gel showing the effect of NF-κB on the palindromic DNA-recognition target. NF-κ...
The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodimeric com...
<p>(A) Chemical structure of VM26 and three positive hits, betulinic acid, <i>DDI</i> and <i>CET</i>...
<p>RAW264.7 cells were cultured for 1 hour with LPS (1 µg/mL) and gentiolactone (250, 500, 1000 µM)....
<p> (<b>A</b>) Variance accounted for by each of the principal components (PCs). (<b>B–D</b>) Scatte...
<p>(A) Levels of p-IκBα with or without treatment in response to TNF-α were determined by western bl...
<p>First, compounds from The Natural Products Set II were tested in two melanoma cell lines obtained...
<p>(A) Western blot analysis to see the nuclear and cytosolic expression of NF-κB in MDA-MB 231 cell...
A) Yeast-two hybrid (Y2H) assays testing interactions between selected NF-YBs (full-length protein) ...
<p>A: BPI chromatogram in negative ESI mode. B: BPI chromatogram in positive ESI mode. C: The bioact...
<p>Samples were loaded on a 2% agarose gel in TAE (1x) buffer. Lanes containing Nupr1 + non-damaged-...
<p>To determine the effect of compounds on the blockage of Pol-β-activity, we assembled <i>in vitro<...
<p>Compounds tested as inhibitors of the NF-κB:DNA-recognition target complex formation.</p
The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodi-meric co...
<div><p>The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodim...
<p><b>a)</b> Agarose gel showing the effect of NF-κB on the palindromic DNA-recognition target. NF-κ...
The nuclear factor κB (NF-κB) is a promising target for drug discovery. NF-κB is a heterodimeric com...
<p>(A) Chemical structure of VM26 and three positive hits, betulinic acid, <i>DDI</i> and <i>CET</i>...
<p>RAW264.7 cells were cultured for 1 hour with LPS (1 µg/mL) and gentiolactone (250, 500, 1000 µM)....
<p> (<b>A</b>) Variance accounted for by each of the principal components (PCs). (<b>B–D</b>) Scatte...
<p>(A) Levels of p-IκBα with or without treatment in response to TNF-α were determined by western bl...
<p>First, compounds from The Natural Products Set II were tested in two melanoma cell lines obtained...
<p>(A) Western blot analysis to see the nuclear and cytosolic expression of NF-κB in MDA-MB 231 cell...
A) Yeast-two hybrid (Y2H) assays testing interactions between selected NF-YBs (full-length protein) ...
<p>A: BPI chromatogram in negative ESI mode. B: BPI chromatogram in positive ESI mode. C: The bioact...
<p>Samples were loaded on a 2% agarose gel in TAE (1x) buffer. Lanes containing Nupr1 + non-damaged-...
<p>To determine the effect of compounds on the blockage of Pol-β-activity, we assembled <i>in vitro<...