<p>Monkeys were infected with <i>T. b. rhodesiense</i> KETRI 2537 and upon confirmation of onset of second stage HAT, treated with (<b>A</b>) DB829 or (<b>B</b>) DB868. DB829 was administered intramuscularly for either 5 consecutive days (28–32 days post-infection) or 5 alternate (*) days (28, 30, 32, 34 and 36 days post-infection). DB868 was administered orally for 10 consecutive days (28–37 days post-infection). Symbols represent means (<b>A</b>; n = 2) or means and standard error of the mean (<b>B</b>; n = 4).</p
<p>The monkeys confirmed to have first stage HAT were administered DB868 orally, beginning at 7 days...
<p>Key: ID = identity in the laboratory; PP = pre-patent period; DPI = days post infection; CSF = ce...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-...
<p>The monkeys (n = 4) were administered DB868 orally at 30 mg/kg/day for 10 days, day −9 to day 0 p...
<p>Starting at 7 days post-infection with <i>T. b. rhodesiense</i> KETRI 2537, monkeys confirmed to ...
<p>Symbols and error bars represent means and SEs, respectively, of seven monkeys that were treated ...
<p>Panel A: MCV; Panel B: MCH; and Panel C: RDW. Note that while both MCV and MCH decreased below pr...
<p>Symbols and error bars represent means and SEs, respectively, of 7 animals; monkeys were treated ...
<p>Key: d, day;DPI, days post-infection; DPT, days post-treatment (post-last drug dose of DB829 or D...
<p>Monkeys were infected with <i>T. b. rhodesiense</i> KETRI 2537 on Day 0. Symbols represent means ...
<p>Monkeys confirmed to have second stage HAT were administered DB868 orally, beginning at 28 days p...
<p>Monkeys confirmed to have second stage HAT were administered DB829 intramuscularly, beginning at ...
<p>Key: DPI, days post-infection; P, parasitaemia; CSF, cerebrospinal fluid; EoT, end of treatment; ...
<p>DB868 was administered orally at 20 mg/kg/day (689M), 10 mg/kg/day (688M), or 3 mg/kg/day (687M) ...
<p>The monkeys confirmed to have first stage HAT were administered DB868 orally, beginning at 7 days...
<p>Key: ID = identity in the laboratory; PP = pre-patent period; DPI = days post infection; CSF = ce...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-...
<p>The monkeys (n = 4) were administered DB868 orally at 30 mg/kg/day for 10 days, day −9 to day 0 p...
<p>Starting at 7 days post-infection with <i>T. b. rhodesiense</i> KETRI 2537, monkeys confirmed to ...
<p>Symbols and error bars represent means and SEs, respectively, of seven monkeys that were treated ...
<p>Panel A: MCV; Panel B: MCH; and Panel C: RDW. Note that while both MCV and MCH decreased below pr...
<p>Symbols and error bars represent means and SEs, respectively, of 7 animals; monkeys were treated ...
<p>Key: d, day;DPI, days post-infection; DPT, days post-treatment (post-last drug dose of DB829 or D...
<p>Monkeys were infected with <i>T. b. rhodesiense</i> KETRI 2537 on Day 0. Symbols represent means ...
<p>Monkeys confirmed to have second stage HAT were administered DB868 orally, beginning at 28 days p...
<p>Monkeys confirmed to have second stage HAT were administered DB829 intramuscularly, beginning at ...
<p>Key: DPI, days post-infection; P, parasitaemia; CSF, cerebrospinal fluid; EoT, end of treatment; ...
<p>DB868 was administered orally at 20 mg/kg/day (689M), 10 mg/kg/day (688M), or 3 mg/kg/day (687M) ...
<p>The monkeys confirmed to have first stage HAT were administered DB868 orally, beginning at 7 days...
<p>Key: ID = identity in the laboratory; PP = pre-patent period; DPI = days post infection; CSF = ce...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...