<p>Key: ID = identity in the laboratory; PP = pre-patent period; DPI = days post infection; CSF = cerebrospinal fluid; Tryps = trypanosomes; WC = white cells; EoT = end of treatment; ToC = test of cure; Neg = Negative; Pos = positive; WD = withdrawn from the experiment after 10<sup>th</sup> drug dose due to toxicity; Numbers in square brackets = maximum number of white cell counts observed during any of the four weekly samplings between 0–27 DPI; I: DB844 5 mg/kg×10 days per os; 28–37 DPI; II: DB844 6 mg/kg×14 days per os; 28–41 DPI.</p
<p>(A) Eight rhesus macaques were infected with SIVmac251 and CD8 T lymphocyte depleted on 6, 8 and ...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...
<p>DB868 was administered orally at 20 mg/kg/day (689M), 10 mg/kg/day (688M), or 3 mg/kg/day (687M) ...
<p>Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-...
<p>Key: DPI, days post-infection; P, parasitaemia; CSF, cerebrospinal fluid; EoT, end of treatment; ...
<p>Key: d, day;DPI, days post-infection; DPT, days post-treatment (post-last drug dose of DB829 or D...
<p>Symbols and error bars represent means and SEs, respectively, of 7 animals; monkeys were treated ...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Monkeys were infected with <i>T. b. rhodesiense</i> KETRI 2537 and upon confirmation of onset of ...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Key: P = parasitaemia; EoT = end of treatment; Neg = negative; Pos = positive; WD = withdrawn.</p
<p>Starting at 7 days post-infection with <i>T. b. rhodesiense</i> KETRI 2537, monkeys confirmed to ...
<p>Symbols and error bars represent means and SEs, respectively, of seven monkeys that were treated ...
<p>Symbols and error bars represent geometric means and SEs, respectively, for DB844 (△) and DB820 (...
<p>Monkeys confirmed to have second stage HAT were administered DB868 orally, beginning at 28 days p...
<p>(A) Eight rhesus macaques were infected with SIVmac251 and CD8 T lymphocyte depleted on 6, 8 and ...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...
<p>DB868 was administered orally at 20 mg/kg/day (689M), 10 mg/kg/day (688M), or 3 mg/kg/day (687M) ...
<p>Key: RBC = red blood cells; WBC = White blood cells; g/dl = grams/decilitre; fl = femtolitres; p-...
<p>Key: DPI, days post-infection; P, parasitaemia; CSF, cerebrospinal fluid; EoT, end of treatment; ...
<p>Key: d, day;DPI, days post-infection; DPT, days post-treatment (post-last drug dose of DB829 or D...
<p>Symbols and error bars represent means and SEs, respectively, of 7 animals; monkeys were treated ...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Monkeys were infected with <i>T. b. rhodesiense</i> KETRI 2537 and upon confirmation of onset of ...
<p>Key: dpi = days post infection; T.b.r. = <i>Trypanosoma brucei rhodesiense</i>; a = Laboratory nu...
<p>Key: P = parasitaemia; EoT = end of treatment; Neg = negative; Pos = positive; WD = withdrawn.</p
<p>Starting at 7 days post-infection with <i>T. b. rhodesiense</i> KETRI 2537, monkeys confirmed to ...
<p>Symbols and error bars represent means and SEs, respectively, of seven monkeys that were treated ...
<p>Symbols and error bars represent geometric means and SEs, respectively, for DB844 (△) and DB820 (...
<p>Monkeys confirmed to have second stage HAT were administered DB868 orally, beginning at 28 days p...
<p>(A) Eight rhesus macaques were infected with SIVmac251 and CD8 T lymphocyte depleted on 6, 8 and ...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...
<p>DB868 was administered orally at 20 mg/kg/day (689M), 10 mg/kg/day (688M), or 3 mg/kg/day (687M) ...