6‑(Bromomaleimido)hexanoic Acid as a Connector for the Construction of Multiple Branched Peptide Platforms

We report on a novel and user-friendly platform based on a bromomaleimide moiety to obtain branched peptides. The platform is stable for all SPPS conditions. The bromomaleimide core was conjugated to <i>n</i>-copies of thiol–peptide in-solution to obtain two/four/eight-armed dendrimers. Using ‘<i>n</i>’ number of bromomaleimide analogues, 2^<i>n</i> ligands were incorporated at both bromo and ene positions via a thioether bond. This method has the advantage of high conversion in a short time, thus enabling effortless purification and characterization processes