Add to ORKGBromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an ...
Methods to constrain peptides in a bioactive α‐helical conformation for inhibition of protein‐protei...
The quest for novel aqueous chemical strategies that allow chemo-, regio- and site-selective modific...
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide contai...
Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconju...
Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing a...
The maleimide motif is widely used for the selective chemical modification of cysteine residues in p...
The maleimide motif is widely used for the selective chemical modification of cysteine residues in p...
The application of chemical methods to biological systems has led to great advances in all life scie...
Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conj...
The application of chemical methods to biological systems has led to great advances in all life scie...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2018.Cataloged from ...
Reversible protein biotinylation is readily affected via conjugation with a bromomaleimide-based rea...
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging ...
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging ...
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an ...
Methods to constrain peptides in a bioactive α‐helical conformation for inhibition of protein‐protei...
The quest for novel aqueous chemical strategies that allow chemo-, regio- and site-selective modific...
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide contai...
Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconju...
Tools that facilitate the chemical modification of peptides and proteins are gaining an increasing a...
The maleimide motif is widely used for the selective chemical modification of cysteine residues in p...
The maleimide motif is widely used for the selective chemical modification of cysteine residues in p...
The application of chemical methods to biological systems has led to great advances in all life scie...
Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conj...
The application of chemical methods to biological systems has led to great advances in all life scie...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2018.Cataloged from ...
Reversible protein biotinylation is readily affected via conjugation with a bromomaleimide-based rea...
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging ...
Chapter 1: The chemical modification and bioconjugation of proteins is an expanding yet challenging ...
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an ...
Methods to constrain peptides in a bioactive α‐helical conformation for inhibition of protein‐protei...
The quest for novel aqueous chemical strategies that allow chemo-, regio- and site-selective modific...