Viral load distributions and transmission potential estimated from patient cohorts as extracted from the corresponding graphs in Fraser et al. [6].

<p>(<b>A</b>) The viral load distributions in the a Zambian and a Dutch cohort (see Fraser et al. [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004634#ppat.1004634.ref006" target="_blank">6</a>]). The lines correspond to the best fits of a Gaussian to the distribution of log spVL. The null hypothesis that log spVL is normally distributed cannot be rejected based on a test that tests whether the residuals between model and fit themselves are normally distributed. The estimated mean and standard deviation are 4.74 and 0.61 for the Zambian data (red) and 4.35 and 0.47 for the Amsterdam data (blue). (<b>B</b>) The transmission probability according to the functions for transmissibility and duration of disease as a function of viral load as provided in Fraser et al. [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004634#ppat.1004634.ref006" target="_blank">6</a>]. The grey circles and lines represent the mean and 95% confidence interval of the transmission potential as estimated from the Zambian and Amsterdam cohorts by Fraser et al. [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004634#ppat.1004634.ref006" target="_blank">6</a>]. The blue line represents the corresponding theoretically derived transmission potential as provided by Fraser et al. [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004634#ppat.1004634.ref006" target="_blank">6</a>]. The red line corresponds to the best fit of a log Gaussian to the estimated transmission potential. The parameters of the fitted log Gaussian are <i>μ</i>_<i>o</i> = 4.64±0.021 and <i>ν</i>_<i>o</i> = 0.96±0.025 (estimate ± standard deviation).