PTX3 modulates RRV replication and disease onset in mice.

<p>(A) 21-day-old C57BL/6 WT and PTX3^-/- mice were infected subcutaneously with 10⁴ PFU RRV. Disease scores were measured at 24 h intervals. Data are presented as mean ± SEM and are representative of 2 independent experiments. *<i>P</i> < 0.05, **<i>P</i> < 0.01, ***<i>P</i> < 0.001, two-way ANOVA, Bonferroni post-test. RRV titres in serum, ankle joint and quadriceps of RRV-infected WT and PTX3^-/- mice (<i>n</i> = 3–7 per group) at (B) 2 and (C) 10 dpi were determined by plaque assay. Data are presented as mean ± SEM and are representative of 2 independent experiments. *<i>P</i> < 0.05, **<i>P</i> < 0.01, Student unpaired <i>t</i>-test.