Increase of melanoma lung nodules in DJ-1 KO mice.

<p>(A) B16F10 cells (6×10⁴) were intravenously injected into both WT and DJ-1 KO mice. Three weeks later, mice were sacrificed. Gross images showed the melanoma nodules (arrows in upper panel), and histological images showed the tumor masses (arrows in lower panel) in lungs of WT and DJ-1 KO mice. Scale bar: 1 mm for photographs and 0.2 mm for H&E staining. (B) Bar chart showed the summarized results of lung nodule numbers in WT and DJ-1 KO mice. Note that melanoma lung nodules increased in DJ-1 KO mice. Data are presented as mean ± S.E.M. n = 12, for each group, * P < 0.05 compared with WT mice.