Bcl-2 family members recognize different inhibitors using distinct surface pockets.

<p>In all cases color gradient indicates the similarity between complexes, expressed as Z-scores (<i>green</i> are most similar, <i>red</i> are most dissimilar). (A) Chemical similarity of the inhibitors. (B) Three-dimensional similarity of the inhibitors’ active conformation. (C) Similarity of protein surface pockets, measured using exemplar similarity. Numbering in all cases corresponds to complexes in <b><a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004081#pcbi.1004081.s010" target="_blank">S1 Table</a></b>. A representative subset of the complexes are included in this figure; a corresponding figure containing all available complexes is available as <b><a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004081#pcbi.1004081.s002" target="_blank">S2 Fig</a></b>.