Effect of ESa on carrageenan-induced edema and neutrophil migration and on lipopolysaccharide-induced fever.

<p>Animals were treated with ethanolic extract form <i>S</i>. <i>aggregata</i> (ESa, 10 to 100 mg/kg, as indicated), Dexamethasone (Dex, 1 mg/kg), or the appropriate vehicles (Veh) by oral route. One hour after the oral treatment animals were injected with carrageenan (Cg, 300 μg) in the paw (panels A and B) or LPS (100 μg/kg, i.p, panel C). On panel B, the control (C) animals are non-injected animals. Data show the mean ± s.e.mean of the change in the paw thickness (μm, panel A), optical density (D.O./mg protein, panel B) or body temperature (°C, panel C) (n = 7–14). Symbols denote statistical difference in relation to the control (C) or Veh/Sal group (* <i>P</i><0.05, **<i>P</i><0.01) or to Veh/Cg (^#p<0.05).