Complex 5 suppresses acute inflammatory responses <i>in vivo</i>.

<p>Male C57BL/6 mice at age of 8-12 weeks old were non-injected or injected i.p. with 2.5 mg/kg or 5.0 mg/kg complex 5, whereas for positive controls, mice were injected i.p. with 2.0 mg/kg dexamethasone. After 1 h, acute inflammation was induced in the right hind paw of each mice by injecting 50 µl of carrageenan. The size of the paw were measured after (A) 1 h or, (B) 1, 3 and 5 h post carrageenan injection. Shown were mean ±SD (n = 4). Statistical analysis was performed with Student's <i>t</i>-test. At 1 h post-carrageenan induction, control versus 2.5 mg/kg complex <b>5</b> (P<0.05), control versus 5.0 mg/kg complex <b>5</b> (P<0.01), and control versus 2.0 mg/kg dexamethasone (P<0.01).