Hierarchical clustering.

<p>Expression of genes modulated >1.5x by hemozoin in erythroid cells before treatment (E1_d0), after incubation for 24 hours with hemozoin (E1H_d1) or TNF-α (E1T_d1) and without treatment in culture medium (E1m_d1) are shown, together with previously described sorted populations of erythroblasts [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119836#pone.0119836.ref026" target="_blank">26</a>]. Hierarchical clustering by gene and experiment (Pearson correlation) is shown centred around these hemozoin- modulated genes (A) or TNF-α- modulated genes (B). CFUE, colony forming unit erythroid FACsorted; ProE, pro- erythroblast FACsorted; Int, Intermediate erythroblast FACsorted; LateE, Late erythroblast sorted; E1, magnetic bead sorted erythroblasts; m, medium; T, TNF-α; H, hemozoin.