<p>Comparisons of the full analytical solution (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004149#pcbi.1004149.e008" target="_blank">Equation 7</a>, with Π given by <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004149#pcbi.1004149.e013" target="_blank">Equation 10</a>) with simulation results. Solid lines represent analytical solutions; points are simulation calculations. Graphs are plotted as a function of the reproductive ratio of the second strain, <i>R</i><sub>2</sub>. Note that the <i>y</i> axis is plotted on a log scale. Different colours denote different mutation rates, as shown in the accompanying legend. Other parameters are (A and B) <i>K</i> = 100, <i>R</i><sub>1</sub...
<p>The parameters are as follows: The maximal virus load equals , and the population size equals . (...
<p>The solution to the system <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal....
<div><p>(A) The ratio of the percentage of cells infected with the recombinant 4, <i>f</i>, and the ...
<p>For all five parameter combinations, we use <i>c</i> = 10<sup>−11</sup>. Most simulations reach e...
<p>Markers indicate numerically obtained data using the following parameters set. <i>T</i> = 1, <i>λ...
<p>A–D) Comparison between experimental data (solid lines) and simulations (dotted lines) using para...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
<p>The discs mark the experimental mean, while the shaded region shows the standard error of the mea...
<p>(a) Comparing the number of mutants for a high value of the proliferation probability, <i>v</i> =...
<p><b>A.</b> The three genetic arrangements, in simulated diploid chromosomes. Key measurements of e...
<p>Comparison of simulation outcomes and analytical solutions for Experiment 2, using the refined me...
<p>The parameters used in the simulations were selected from the ranges of and . The convergence co...
<p>Simulation data (red open symbols) represents mean effective dose for the model at the optimal fi...
<p>Averages over 100 independent simulations are shown, see <a href="http://www.plosone.org/article/...
<p>As in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076195#pone-0076195-...
<p>The parameters are as follows: The maximal virus load equals , and the population size equals . (...
<p>The solution to the system <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal....
<div><p>(A) The ratio of the percentage of cells infected with the recombinant 4, <i>f</i>, and the ...
<p>For all five parameter combinations, we use <i>c</i> = 10<sup>−11</sup>. Most simulations reach e...
<p>Markers indicate numerically obtained data using the following parameters set. <i>T</i> = 1, <i>λ...
<p>A–D) Comparison between experimental data (solid lines) and simulations (dotted lines) using para...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
<p>The discs mark the experimental mean, while the shaded region shows the standard error of the mea...
<p>(a) Comparing the number of mutants for a high value of the proliferation probability, <i>v</i> =...
<p><b>A.</b> The three genetic arrangements, in simulated diploid chromosomes. Key measurements of e...
<p>Comparison of simulation outcomes and analytical solutions for Experiment 2, using the refined me...
<p>The parameters used in the simulations were selected from the ranges of and . The convergence co...
<p>Simulation data (red open symbols) represents mean effective dose for the model at the optimal fi...
<p>Averages over 100 independent simulations are shown, see <a href="http://www.plosone.org/article/...
<p>As in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0076195#pone-0076195-...
<p>The parameters are as follows: The maximal virus load equals , and the population size equals . (...
<p>The solution to the system <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal....
<div><p>(A) The ratio of the percentage of cells infected with the recombinant 4, <i>f</i>, and the ...